Yu-Gi-Oh! GX: The Beginning of Destiny does a pretty good job of laying out the menus and controls in such a way that you will get a feel for them quickly. You can go to each of the battle phases by tapping the Circle button and navigating to the phase you want to jump to, while the (R1) button is used to move your cursor between your hand and the field, and the (X) button brings up the list of choices you have concerning the card you are hovering over. This is pretty much all you need. When you want to take a card out of your hand and put it on the field, you select the card with (X), and choose whether you want to summon/use it or set it. When you want to mess with a card that is already on the field, just select it and you will be presented with the available list of options. If it is the battle phase, you can attack with it, if it is another phase, you can flip-summon the monster, or activate the trap/magic item.
When your opponent activates a trap, the game automatically asks you if you want to activate one of your traps (provided you have some) in order to create a chain. It is aspects like this that make dueling easier because you might forget, while in an actual duel, that you can chain traps. Though, I do have a couple of beefs - one is the quality of the image of the card even when in "detail view." While this gives you a full list of the text and really everything you need to know to actually play the game, the images on the cards are a lot of the draw, and the pixilated versions just aren't all that great. The other aspect is the game's frequent asking if you want to view the details of a card. I understand this from a developmental point of view. If the enemy places a card on the field, you should definitely let the player see it in more detail, as well as if they flip or activate a card. But I found that I was asked two or three times in a turn if I wanted to view a card. This wouldn't be as big an issue if the default selection was No, but because it is Yes, I found myself tapping (X) and saying Yes, then having to go back out and continue what I wanted to do. I think the best option would be to have Yes be the default until I actually view the card, then any time it wants to know if I need to see if after that, default the option to No. But that was really a minor annoyance.
In the end, I think Yu-Gi-Oh! GX: The Beginning of Destiny is a good game for both TCG fans that are new to the title and veterans who know how to play the game while standing on their heads. The tutorial battle does a great job of getting you ready for standard duels, and the ability to challenge a wide variety of opponents in any order means that long-time players won't get bored with the simpler strategy-characters.